Quantification of the distribution of 111In-labelled platelets in organs
Identifieur interne : 000790 ( Main/Exploration ); précédent : 000789; suivant : 000791Quantification of the distribution of 111In-labelled platelets in organs
Auteurs : RBID : ISTEX:259_1982_Article_BF00251649.pdfAbstract
A simple and practical approach to the in vivo quantification of 111indium-oxine labelled blood platelets with a scintillation camera and computer assisted imaging system was evaluated. Radioactivity of the 172 and 247 keV energies was measured in a phantom at various source distances from the collimator and the accuracy of anterior and posterior mode measurements compared with that of the geometrical mean (GM) method, with and without correction for Compton scatter (CS). Organ radioactivity, expressed as a percentage of whole body radioactivity, was determined in vivo in five baboons and the accuracy of the methods verified by post mortem quantification in the animals. Measurement in the anterior mode significantly overestimates hepatic and underestimates splenic radioactivity; posterior mode quantification reverses these results. Correction with the GM method made the accuracy and reproducibility very acceptable. Further correction for anterior-posterior attenuation and/or CS did not improve results materially. The GM method could readily be applied in five human subjects. This study shows that the GM method is an accurate and practical method for the in vivo quantification of organ and regional distribution of 111In-labelled platelets.
DOI: 10.1007/BF00251649
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Lötter</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author><author><name>A. du P. Heyns</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author><author><name>F. de Kock</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author><author><name>C. Herbst</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author><author><name>H. Kotzé</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author><author><name>H. Pieters</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author><author><name>P. C. Minnaar</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author><author><name>P. N. Badenhorst</name><affiliation wicri:level="1"><mods:affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</mods:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of the Orange Free State Medical School, Bloemfontein</wicri:regionArea><wicri:noRegion>Bloemfontein</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:259_1982_Article_BF00251649.pdf</idno><date when="1982">1982</date><idno type="doi">10.1007/BF00251649</idno><idno type="wicri:Area/Main/Corpus">000951</idno><idno type="wicri:Area/Main/Curation">000951</idno><idno type="wicri:Area/Main/Exploration">000790</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">A simple and practical approach to the in vivo quantification of 111indium-oxine labelled blood platelets with a scintillation camera and computer assisted imaging system was evaluated. Radioactivity of the 172 and 247 keV energies was measured in a phantom at various source distances from the collimator and the accuracy of anterior and posterior mode measurements compared with that of the geometrical mean (GM) method, with and without correction for Compton scatter (CS). Organ radioactivity, expressed as a percentage of whole body radioactivity, was determined in vivo in five baboons and the accuracy of the methods verified by post mortem quantification in the animals. Measurement in the anterior mode significantly overestimates hepatic and underestimates splenic radioactivity; posterior mode quantification reverses these results. Correction with the GM method made the accuracy and reproducibility very acceptable. Further correction for anterior-posterior attenuation and/or CS did not improve results materially. The GM method could readily be applied in five human subjects. This study shows that the GM method is an accurate and practical method for the in vivo quantification of organ and regional distribution of 111In-labelled platelets.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="a7bd11cb263298ebb38fb66a6f61b88661a28125"><titleInfo lang="eng"><title>Quantification of the distribution of 111In-labelled platelets in organs</title></titleInfo><name type="personal"><namePart type="given">O.</namePart><namePart type="family">van Reenen</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Blood Platelet Research Unit of the S.A. Medical Research Council, Universitas Hospital, Bloemfontein, South Africa</affiliation><affiliation>University of the Orange Free State Medical School, Bloemfontein, South Africa</affiliation></name><name type="personal"><namePart type="given">M. 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Radioactivity of the 172 and 247 keV energies was measured in a phantom at various source distances from the collimator and the accuracy of anterior and posterior mode measurements compared with that of the geometrical mean (GM) method, with and without correction for Compton scatter (CS). Organ radioactivity, expressed as a percentage of whole body radioactivity, was determined in vivo in five baboons and the accuracy of the methods verified by post mortem quantification in the animals. Measurement in the anterior mode significantly overestimates hepatic and underestimates splenic radioactivity; posterior mode quantification reverses these results. Correction with the GM method made the accuracy and reproducibility very acceptable. Further correction for anterior-posterior attenuation and/or CS did not improve results materially. The GM method could readily be applied in five human subjects. This study shows that the GM method is an accurate and practical method for the in vivo quantification of organ and regional distribution of 111In-labelled platelets.</abstract><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1982</partNumber><partNumber>Volume: 7</partNumber><partNumber>Number: 2</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1982-02-01</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 15</identifier><recordInfo><recordOrigin>Springer-Verlag, 1982</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00251649</identifier><identifier type="matrixNumber">Art9</identifier><identifier type="local">BF00251649</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>80</start><end>84</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1982</recordOrigin><recordIdentifier>259_1982_Article_BF00251649.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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